Using Mass Spectrometry for Drug Metabolism Studies, Second Edition

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Product Description

The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices. The stand-alone chapters cover various topics � from metabolite identification to fast chromatography with UPLC � and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART. With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.

Using Mass Spectrometry for Drug Metabolism Studies, Second Edition Review

Although the fist edition of this book is still quite useful, there have been enough improvements and novel innovations in the past 6-7 years, it is worth making use of this new edition. Of particular interest are the recent advances in chromatography, as well as ionization interfaces that are already showing promising appications for DMPK work. Like the first edition, each chapter is clearly written by people that use the technique for their work, as the examples are very relevant to the DMPK scientist. Each of the covered techniques contains enough background material to allow even the novice to get started, and the references will be of interest to the more advanced reader. Both quantitative and qualitative applications are covered in the chapters, as well as the strategies by which they are put into place in the DMPK setting. The experienced mass spec person within DMPK will appreciate the comprehensive nature of the material in this book, while the many collaborating scientists from chemistry, biology, pharmacology, pharmacokinetics will learn enough to get a better understanding of what mass spectrometry can do for drug metabolism studies. If you have one book on your shelf in this area, this should be it!

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