Neural Circuit Development and Function in the Healthy and Diseased Brain: Comprehensive Developmental Neuroscience

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The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 3 offers 40 high level articles devoted mainly to anatomical and functional development of neural circuits and neural systems, as well as those that address neurodevelopmental disorders in humans and experimental organisms.

• Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop
• Features leading experts in various subfields as Section Editors and article Authors
• All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship
• Volume 3 sections include coverage of: mechanisms that control the assembly of neural circuits in specific regions of the nervous system, multiple aspects of cognitive development, and disorders of the nervous system arising through defects in neural development

Neural Circuit Development and Function in the Healthy and Diseased Brain: Comprehensive Developmental Neuroscience Review

Developmental Neuroscience just received a major, much needed update with this series. This is volume 3 (volume 2 won't be out for a month or two at this writing), which covers the "final" episode in the trilogy: circuit development. Volume one contains 48 chapters on initial patterning and cell specification and specialization in both the CNS and PNS.

Volume two continues the developmental saga with 56 chapters ranging from cell and axon migration to synaptogenesis, which naturally leads to the present volume on actual neural circuitry in both normal and pathological development.

The authors correctly point out that the past 5 years have shown an avalanche of new molecular, genetic and cell mediated discoveries and information. They also demonstrate that this information is poorly categorized, referenced, notated, organized and especially synthesized. So, to heal siloed research cottages, why use monographs?

The answer itself is in the organization-- the editors have chosen sub editors in each field, allowed them to choose the most cutting edge researchers and practitioners as authors, then tied the nearly 3,000 page series together with a Herculean effort toward the needed synthesis.

I won't opine on whether they achieved it, but they certainly have updated a much needed bibliography in the field with the best and brightest. The series is all color, and the plates worthy of 2013-- ideal for numerous spin off classes utilizing their Powerpoints. State of the art topics such as time-dependent plasticity, neonatal cortical rhythms, form and functional auditory and olfactory circuits, and many other exemplary topics comprehensively illustrate the major stages of the various developmental timetables and their genetic, molecular and cellular triggers and modulators. Many of the inline and bib references are very recent, the majority this century.

Our library clients are clamoring for this series, particularly university, graduate and of course medical and neuro libraries, and there are already printing delays on the first two volumes. Even though in monograph form, since the information is encyclopedic, this series will likely achieve a trifecta of reference, teaching and research audiences immediately. We've not completed the normal quality scoring we do for new editions due to the quantity and density of information, but at a 33% level of completion, we've found very few typos and errors in the first two volumes. We will update when the series is complete. Pedagogically the authors take a "journal" like tone, without wasting time and space on teaching USE, but carefully tying chapters together with scope descriptions, summaries, content cross references, etc. Due to both the quality and sheer volume of information, numerous course structures will be possible.

Although the level and organization are graduate level, the editors must have been subject to many ground rules, because the monographs are consistent not only in quality and currency, but also presentation. For example, unlike many journals in this field, the first time each abbreviation or acronym is used, in EACH article, the definition is given, in context. If an author refers to a BM near the organ of Corti, she also gives a parenthetical ("Basal Membrane") and digresses enough to "remind" the novice reader of the chemical and energy translation properties of the organ. If you're actively researching the field you might find this delaying; but it is done succinctly and with enough novel information to possibly even make a connection you've missed (for example, the relationship of mechanical motion to traveling waves and channel depolarization via K+ influx).

If you are in the field, I don't have to tell you about the number of abbreviations and acronyms that have taken over the discipline! This is just one more evidence that the authors and editors are not doing the journal dance of "look how smart I am," as much as helping the student/researcher - reader understand. The indices, web resources and inline citations/ chapter bibs are not only extensive, but organized with an eye to the continuing reference value of these extraordinary volumes. Highly recommended. My field is supercomputer applications in RNA folding and molecular modeling, without any narrow specialization in neuro other than a few particularly interesting animal model candidates for research.

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