Oxidative Stress and Signal Transduction

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Product Description

In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.

Oxidative Stress and Signal Transduction Review

Those investigators wondering what does oxidative stress mean to cell function will find in this book a new perspective. Written in an accesible language of basic cell biology, the text covers a broad range of subjects in an clear, orderly manner. Helpful in the formulation of mechanistic hypotheses for those interested in the pathophysiology and pharmacology of inflammation, cancer or aging, among others. The authors include some "big names" but are mostly mid-career and young investigators whose refreshing views, combined with the experience of the editors in the field make the book unusually exciting and meaningful.

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