Advances in Amino Acid Mimetics and Peptidomimetics, Volume 1, Volume 1

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Peptidomimetics are compounds which mimic the biological activity of peptides while offering the advantages of increased bioavailability, biostability, bioefficiency, and bioselectivity against the natural biological target of the parent peptide. Examples of peptidomimetics have been isolated as natural products, synthesized as libraries from novel subunits, and designed on the basis of X-ray crystallographic studies and through an intricate knowledge of the biological mode of action of natural peptides. They offer challenging synthetic targets and are increasingly important medicinal agents and biological probes. As a consequence, peptidomimetics embrace much of what is modern medicinal and organic chemistry. This volume highlights some recent and exciting developments in the area.

Advances in Amino Acid Mimetics and Peptidomimetics, Volume 1, Volume 1 Review

This book presents a new domain, whose applications might be greatly increased in the coming years. Construction of peptidomimetic molecules it a useful tool for the development of new drugs. The major drawback of peptides as possible drugs is their poor bioavailability and their degradation in the body. Therefore, molecules resembling the tertiary structures of interesting peptides, but having more suitable bioavailability properties might proove very useful as candidate drugs. That is why this discipline is very promising. To date, i haven't found any text books addressing this issue, this book might be the first one. I liked the fact that its contents cover many medical domains. However, I would have liked that the authors have addressed the problem of increasing bacterial resistance, the need to develop new antibacterials, and eventually the possible role of peptidomimetics in that field. Another thing that i would have liked to find in the contents, is a brief review on the phage display technique, its potential of finding useful peptides that might serve for the construction of peptidomimetics.

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