American Trypanosomiasis (World Class Parasites)

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American trypanosomiasis, or Chagas disease, is caused by the protozoan parasite, Trypanosoma cruzi. Sixteen to eighteen million people are currently infected with this organism, and 45,000 deaths are attributed to the disease each year. Infection with T. cruzi is life-long, and 10-30% of persons who harbor the parasite chronically develop cardiac and gastrointestinal problems associated with the parasitosis. Although major progress has been made in recent years in reducing vector-borne and transfusion-associated transmission of T. cruzi, the burden of disability and death in persons chronically infected with the organism continues to be enormous. Eight to ten million persons born in countries in which Chagas disease is endemic currently reside in the United States, and epidemiologic and census data suggest that 50,000-100,000 are chronically infected with T. cruzi. The presence of these infected persons poses a risk of transmission of the parasite in the USA through blood transfusion and organ transplantation and several such cases have now been documented.

American Trypanosomiasis, volume seven of World Class Parasites is written for students of tropical medicine, parasitology and public health, for researchers and practitioners alike who wish to bring themselves abreast of the status quo with respect to this disease. It is intended to supplement formal textbooks, in order to broaden and illuminate current areas of scientific and public health concern. Uniquely for T. cruzi, this book addresses parasite, vector and host biology, the pathogenesis of Chagas disease and current and prospective therapeutics and control strategies in a single volume.

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American Trypanosomiasis (World Class Parasites) Review

In the late seventies, the publication of Brener and Andrade's first edition of "Trypanosoma cruzi e Doen a de Chagas" gifted the latin American scientific community with a detailed account of the Chagas' disease research legacy. However, unfortunately this privilege was not extended to the community of researchers, scholars and students that do not understand Portuguese or spanish. Kevin Tyler and Michael Miles have now taken the initiative to fill up this gap by editing "American Trypanosomiasis", a new volume of the Kluwer's World Class parasites series. Organized in 14 chapters, this compact book covers a wide range of relevant topics, is written by some of the best specialists in the field, and is accessible to the non-specialists. Although there is considerable variation in style among chapters and occasional duplication of content, the text is well-written, and will definitively prove a valuable alternative to the scattered reviews that cover each of the specific themes addressed in this volume. Overall, the reading flows well, the chapters nicely blend with each other. In producing the work, the editors have clearly given preference to quality over matters of style. An obvious deficiency of the book was the inconsistent treatment of bibliography; in some chapters, there was excessive use of review citations, which will not making justice to the authors responsible for original discoveries.The book starts with an objective account of T. cruzi life cycle and this is followed by a comprehensive review of T. cruzi cell biology. At the core of the book we find excellent chapters covering developments in molecular genetics, biochemistry and molecular biology. After being introduced to the astounding genetic diversity of T. cruzi, we learn how the pathogens' molecular machinery enables their survival in so many distinct environments. Chapters dealing with signaling pathways are particularly instructive, and some of these texts were adequately supported by schematic illustrations-unfortunately used too modestly thorough the book. The knowledge described in the preceding chapters offers a basis to understand the puzzles faced by research in molecular pathogenesis. After learning how parasite activity may be linked to cardiovascular dysfunction, readers are confronted with different perspectives about immunopathogenesis. It is gratifying to know that conflicting views about role of tissue parasitism and autoimmunity are not as sharp as they used to be decades ago. There is now consensus that myocardial parasitism, although scarce, is nonetheless persistent and most likely essential for the development of chronic cardiomyopathy. Moving into clinical research, readers are then provided with detailed review on the present status of chemotherapy. After learning about the success and limitations of current antiparasite drugs, readers will know of the growing list of potent compounds generated by rational drug design. In the last segment of the book, we learn about genetic mechanisms involved in evolution of Trypanosoma cruzi and triatomines and their impact on the epidemiology of Chagas1 disease. The volume ends with a chapter discussing critically alternative strategies for the control of Chagas disease. In conclusion, American Trypanosomiasis is a fundamental english title, which offers a comprehensive vision of current status of Chagas disease research both to specialists and non-specialists.
Julio Scharfstein, Kinetoplastid Biology and Diesase 2003, 2:9 Help other customers find the most helpful reviews� Was this review helpful to you? Yes No Report abuse | PermalinkComment�Comment

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