Two Faces of Evil: Cancer and Neurodegeneration (Research and Perspectives in Alzheimer's Disease)

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Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes

Two Faces of Evil: Cancer and Neurodegeneration (Research and Perspectives in Alzheimer's Disease) Review

Title: Two Faces of Evil: Cancer & Neurodegeneration

Reviewer: Joseph J Grenier MD PhD

The authors look at the etiology and molecular pathophysiology of several genes involved in cellular demise and cell proliferation. Specifically, they focus upon cyclin D and E genes, immediate early response genes IERs, and the p53 gene. They contend that the cyclin genes control not only the cell cycle but how cells grow and transform their phenotypes. The book is going to be of interest to cell biologists primarily and anyone with an interest in cancer or neurodegeneration.

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